If you consider the harmonic profiles you can see how easily they will work together. In Human Design they call this being a 'harmonic,' or being 'in resonance,' which is just a fu-fu way of saying that it's easier. This is true for every profile to some degree, but I'm noticing that some are more at odds with each other than others. I often think of the man who wrote the Diving Bell and Butterfly, lucidly trapped inside of something you people all around you interacting with who is not you while are there within, unseen.
Being a 5/1 sometimes feels like having locked in syndrome.